ceesdekker.net - An Overview
ceesdekker.net - An Overview
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2009, discovery of a whole new phenotype for micro organism in slender nanofluidic slits; and to start with detection of local protein structures along DNA using strong-state nanopores
Human Rad51 filaments on double- and solitary-stranded DNA: correlating frequent and irregular types with recombination functionality.
Dynamics of initiation, termination and reinitiation of DNA translocation from the motor protein EcoR124I
Considering that 2000, Dekker has shifted the most crucial concentrate of his work in direction of biophysics where by he scientific studies the Houses of one biomolecules and cells using the resources of nanotechnology. This alteration of area was driven by his fascination for that extraordinary functioning of biological molecular constructions, together with by the lengthy-phrase point of view that many intriguing discoveries is often predicted During this field.[5] Present traces of investigation in his biophysics team are during the parts of:[six]
2012, discovery that nucleoid occlusion underlies the precision of bacterial cell division; and to start with at any time study of your dynamics DNA supercoils and the discovery of supercoil hopping
Experimental stage diagram of negatively supercoiled DNA calculated by magnetic tweezers and fluorescence,
What distinguishes biology from chemistry is usually that these elements alongside one another make up a residing system. The key of said lifetime, I think, lies from the interactions, the interplay of All those molecules. The big problem regarding the origin of everyday living continues to be unanswered. How did we at any time evolve from straightforward molecules into your very elaborate methods we see currently? We have no idea. I would like to operate on these kinds of huge, open up questions.’
He also observed time to write various books, send out Nearly forty thousand tweets and guide a successful investigation group at Delft College of Engineering. ‘It doesn’t experience like perform’, he claims. ‘I’m just terribly curious.’
In 1993, being a youthful and eager associate professor at Delft University of Technological know-how, I had originally concentrated the study attempts of my team on measuring the electrical conductance of only one conducting-polymer molecule. Inside of two yrs, we experienced produced a device through which only one wire of a phthalocyaninepolysiloxane polymer was linked involving two intently spaced metal nanoelectrodes.
Presently, we also understood that it ought to be doable to implement one semiconducting carbon nanotube to help make a transistor — and we established out to really make it. We stretched specific semiconducting nanotubes throughout metallic electrodes and applied the underlying silicon substrate being a gate electrode, setting up the basic three-terminal structure of the discipline-impact transistor (Fig.
Tests pseudotopological and nontopological designs for SMC-pushed DNA loop extrusion against roadblock-traversal experiments
Many new phenomena were being uncovered, and he and his study team set up a number one placement Within this ceesdekker industry of investigation. Dekker and his study team found new physics of nanotubes and explored the feasibility of molecular electronics. In 1998, they have been the very first to develop a transistor depending on only one nanotube molecule.
2005, discovery from the system of DNA uncoiling by topoisomerase enzymes; discovery of lengthy-array conformational modifications in Mre11/DNA repair service complexes; and initial pressure measurements on a DNA molecule in the nanopore
The biophysicist from Delft – who has been one of the most cited experts during the Netherlands For some time – can take his accountability to lead towards the explanation and popularisation of his do the job for the border of physics and biology particularly significantly and routinely appears in the media; Otherwise to mention his perform, then about the relationship concerning science and his Christian religion.